[HTML][HTML] Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release
JV Gerasimenko, RM Charlesworth, MW Sherwood… - Cell calcium, 2015 - Elsevier
Intracellular Ca 2+ release is mostly mediated by inositol trisphosphate, but intracellular
cyclic-ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are
important messengers in many systems. Whereas cADPR generally activates type 2
ryanodine receptors (RyR2s), the NAADP-activated Ca 2+ release mechanism is less clear.
Using knockouts and antibodies against RyRs and Two-Pore Channels (TPCs), we have
compared their relative importance for NAADP-induced Ca 2+ release from two-photon …
cyclic-ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are
important messengers in many systems. Whereas cADPR generally activates type 2
ryanodine receptors (RyR2s), the NAADP-activated Ca 2+ release mechanism is less clear.
Using knockouts and antibodies against RyRs and Two-Pore Channels (TPCs), we have
compared their relative importance for NAADP-induced Ca 2+ release from two-photon …
