Triglyceride deposit cardiomyovasculopathy
K Hirano, Y Ikeda, N Zaima, Y Sakata… - New England Journal …, 2008 - Mass Medical Soc
K Hirano, Y Ikeda, N Zaima, Y Sakata, G Matsumiya
New England Journal of Medicine, 2008•Mass Medical SocTo the Editor: A 41-year-old man was admitted to our hospital with ventricular tachycardia in
2003. Biopsy specimens obtained from the right ventricle showed neutral lipid deposition in
cardiomyocytes. In 2004, the patient had catecholamine-dependent congestive heart failure,
and a left ventricular assist system was implanted. Skeletal-muscle atrophy in the arms
became evident, and staining of biopsy specimens with oil red O showed droplets of
predominantly type I fibers (Figure 1A). Levels of plasma lipids and carnitine were normal. In …
2003. Biopsy specimens obtained from the right ventricle showed neutral lipid deposition in
cardiomyocytes. In 2004, the patient had catecholamine-dependent congestive heart failure,
and a left ventricular assist system was implanted. Skeletal-muscle atrophy in the arms
became evident, and staining of biopsy specimens with oil red O showed droplets of
predominantly type I fibers (Figure 1A). Levels of plasma lipids and carnitine were normal. In …
To the Editor: A 41-year-old man was admitted to our hospital with ventricular tachycardia in 2003. Biopsy specimens obtained from the right ventricle showed neutral lipid deposition in cardiomyocytes. In 2004, the patient had catecholamine-dependent congestive heart failure, and a left ventricular assist system was implanted. Skeletal-muscle atrophy in the arms became evident, and staining of biopsy specimens with oil red O showed droplets of predominantly type I fibers (Figure 1A). Levels of plasma lipids and carnitine were normal.
In June 2007, the patient underwent cardiac transplantation. Microscopical examination of the explanted heart revealed numerous vacuoles that stained positive for . . .
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