Dosing time matters

MD Ruben, DF Smith, GA FitzGerald, JB Hogenesch - Science, 2019 - science.org
Science, 2019science.org
Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian
rhythms in vital cardio-metabolic, endocrine, immunologic, and behavioral functions. Time,
therefore, adds a potentially important dimension to medicine. Circadian medicine aims to
incorporate knowledge of 24-hour biological rhythms to enhance diagnosis and treatment.
How is research and technology shaping this endeavor?
Physicians diagnose and administer treatment as needed; time of day is rarely considered. Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian rhythms in vital cardio-metabolic, endocrine, immunologic, and behavioral functions. Time, therefore, adds a potentially important dimension to medicine. Circadian medicine aims to incorporate knowledge of 24-hour biological rhythms to enhance diagnosis and treatment. How is research and technology shaping this endeavor?
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