Variant in PNPLA3 is associated with alcoholic liver disease
C Tian, RP Stokowski, D Kershenobich, DG Ballinger… - Nature …, 2010 - nature.com
Two genome-wide association studies (GWAS) have described associations of variants in
PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the
contributions of these variants to liver disease in Mestizo subjects with a history of alcohol
dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver
disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P= 1.7× 10− 10;
ancestry-adjusted OR= 1.79, P= 1.9× 10− 5).
PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the
contributions of these variants to liver disease in Mestizo subjects with a history of alcohol
dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver
disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P= 1.7× 10− 10;
ancestry-adjusted OR= 1.79, P= 1.9× 10− 5).
Abstract
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 × 10−10; ancestry-adjusted OR=1.79, P=1.9 × 10−5).
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