Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming
B Aguilar-Bravo, S Ariño, D Blaya, E Pose… - Journal of …, 2023 - Elsevier
Background & Aims Loss of hepatocyte identity is associated with impaired liver function in
alcohol-related hepatitis (AH). In this context, hepatocyte dedifferentiation gives rise to cells
with a hepatobiliary (HB) phenotype expressing biliary and hepatocyte markers and
showing immature features. However, the mechanisms and impact of hepatocyte
dedifferentiation in liver disease are poorly understood. Methods HB cells and ductular
reaction (DR) cells were quantified and microdissected from liver biopsies from patients with …
alcohol-related hepatitis (AH). In this context, hepatocyte dedifferentiation gives rise to cells
with a hepatobiliary (HB) phenotype expressing biliary and hepatocyte markers and
showing immature features. However, the mechanisms and impact of hepatocyte
dedifferentiation in liver disease are poorly understood. Methods HB cells and ductular
reaction (DR) cells were quantified and microdissected from liver biopsies from patients with …