Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis
Background & Aims In alcohol-associated hepatitis (AH), inflammation and neutrophil counts
correlate with poor clinical outcomes. Here, we investigated how neutrophils contribute to
liver damage in AH. Methods We isolated blood neutrophils from individuals with AH to
examine neutrophil extracellular traps (NETs) and performed RNA sequencing to explore
their unique characteristics. Results We observed a significant increase in NET production in
AH. We also observed a unique low-density neutrophil (LDN) population in individuals with …
correlate with poor clinical outcomes. Here, we investigated how neutrophils contribute to
liver damage in AH. Methods We isolated blood neutrophils from individuals with AH to
examine neutrophil extracellular traps (NETs) and performed RNA sequencing to explore
their unique characteristics. Results We observed a significant increase in NET production in
AH. We also observed a unique low-density neutrophil (LDN) population in individuals with …