[HTML][HTML] Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: a multicenter randomized trial (GRAFT study)
C Engelmann, A Herber, A Franke, T Bruns… - Journal of …, 2021 - Elsevier
Background & Aims Based on positive results from small single center studies, granulocyte-
colony stimulating factor (G-CSF) is being widely used for the treatment of patients with
acute-on-chronic liver failure (ACLF). Herein, we aimed to evaluate the safety and efficacy of
G-CSF in patients with ACLF. Methods In this multicenter, prospective, controlled, open-label
phase II study, 176 patients with ACLF (EASL-CLIF criteria) were randomized to receive G-
CSF (5 μg/kg daily for the first 5 days and every third day thereafter until day 26) plus …
colony stimulating factor (G-CSF) is being widely used for the treatment of patients with
acute-on-chronic liver failure (ACLF). Herein, we aimed to evaluate the safety and efficacy of
G-CSF in patients with ACLF. Methods In this multicenter, prospective, controlled, open-label
phase II study, 176 patients with ACLF (EASL-CLIF criteria) were randomized to receive G-
CSF (5 μg/kg daily for the first 5 days and every third day thereafter until day 26) plus …