Synergistic associations of PNPLA3 I148M variant, alcohol intake, and obesity with risk of cirrhosis, hepatocellular carcinoma, and mortality
Importance Alcohol drinking and obesity are associated with an increased risk of cirrhosis
and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these
risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-
containing protein 3 (PNPLA3) gene, may play an important role in modulating cirrhosis and
HCC risk. Objective To investigate the joint associations of thePNPLA3I148M variant,
alcohol intake, and obesity with the risk of cirrhosis, HCC, and liver disease–related …
and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these
risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-
containing protein 3 (PNPLA3) gene, may play an important role in modulating cirrhosis and
HCC risk. Objective To investigate the joint associations of thePNPLA3I148M variant,
alcohol intake, and obesity with the risk of cirrhosis, HCC, and liver disease–related …