Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2* 2 …
YC Chen, GS Peng, TP Tsao, MF Wang… - Pharmacogenetics …, 2009 - journals.lww.com
Objectives It has been well documented that although homozygosity of the variant aldehyde
dehydrogenese-2 (ALDH2) gene allele, ALDH2* 2, in Asians almost fully protects against
alcoholism, the heterozygosity only affords a partial protection to varying degrees. The
partial protection against alcoholism has been ascribed to the faster elimination of
acetaldehyde by residual hepatic ALDH2 activity and the lower accumulation in circulation
in nonalcoholic heterozygotes. The physiological basis for overcoming the protection in …
dehydrogenese-2 (ALDH2) gene allele, ALDH2* 2, in Asians almost fully protects against
alcoholism, the heterozygosity only affords a partial protection to varying degrees. The
partial protection against alcoholism has been ascribed to the faster elimination of
acetaldehyde by residual hepatic ALDH2 activity and the lower accumulation in circulation
in nonalcoholic heterozygotes. The physiological basis for overcoming the protection in …