[HTML][HTML] High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis
F Schmalz, J Fischer, H Innes, S Buch, C Möller… - JHEP Reports, 2023 - Elsevier
Background & Aims Progression of alcohol-associated liver disease (ALD) is driven by
genetic predisposition. The rs13702 variant in the lipoprotein lipase (LPL) gene is linked to
non-alcoholic fatty liver disease. We aimed at clarifying its role in ALD. Methods Patients
with alcohol-associated cirrhosis, with (n= 385) and without hepatocellular carcinoma
(HCC)(n= 656), with HCC attributable to viral hepatitis C (n= 280), controls with alcohol
abuse without liver damage (n= 366), and healthy controls (n= 277) were genotyped …
genetic predisposition. The rs13702 variant in the lipoprotein lipase (LPL) gene is linked to
non-alcoholic fatty liver disease. We aimed at clarifying its role in ALD. Methods Patients
with alcohol-associated cirrhosis, with (n= 385) and without hepatocellular carcinoma
(HCC)(n= 656), with HCC attributable to viral hepatitis C (n= 280), controls with alcohol
abuse without liver damage (n= 366), and healthy controls (n= 277) were genotyped …
[CITATION][C] A Lipoprotein-lipase high producer variant may protect from hepatocellular carcinoma in alcohol-associated cirrhosis
F Schmalz, J Fischer, H Innes, S Buch, C Moller… - JHEP Reports, 2023 - EASL