A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease
HD Nischalke, P Lutz, B Krämer, J Söhne, T Müller… - Journal of …, 2014 - Elsevier
Background & Aims The genetic background of alcoholic liver diseases and their
complications are increasingly recognized. A common polymorphism in the neurocan
(NCAN) gene, which is known to be expressed in neuronal tissue, has been identified as a
risk factor for non-alcoholic fatty liver disease (NAFLD). We investigated if this polymorphism
may also be related to alcoholic liver disease (ALD) and hepatocellular carcinoma (HCC).
Methods We analysed the distribution of the NCAN rs2228603 genotypes in 356 patients …
complications are increasingly recognized. A common polymorphism in the neurocan
(NCAN) gene, which is known to be expressed in neuronal tissue, has been identified as a
risk factor for non-alcoholic fatty liver disease (NAFLD). We investigated if this polymorphism
may also be related to alcoholic liver disease (ALD) and hepatocellular carcinoma (HCC).
Methods We analysed the distribution of the NCAN rs2228603 genotypes in 356 patients …