Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules
G Hu, AT Place, RD Minshall - Chemico-biological interactions, 2008 - Elsevier
An important function of the endothelium is to regulate the transport of liquid and solutes
across the semi-permeable vascular endothelial barrier. Two cellular pathways have been
identified controlling endothelial barrier function. The normally restrictive paracellular
pathway, which can become “leaky” during inflammation when gaps are induced between
endothelial cells at the level of adherens and tight junctional complexes, and the
transcellular pathway, which transports plasma proteins the size of albumin via transcytosis …
across the semi-permeable vascular endothelial barrier. Two cellular pathways have been
identified controlling endothelial barrier function. The normally restrictive paracellular
pathway, which can become “leaky” during inflammation when gaps are induced between
endothelial cells at the level of adherens and tight junctional complexes, and the
transcellular pathway, which transports plasma proteins the size of albumin via transcytosis …
