An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo
Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several
mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary
aim of this study was to identify the TIMP-2 region involved in binding to the previously
identified receptor integrin α3β1, and to determine whether synthetic peptides derived from
this region retained angio-inhibitory and tumor suppressor activity. We demonstrated that the
N-terminal domain of TIMP-2 (N-TIMP-2) binds to α3β1 and inhibits vascular endothelial …
mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary
aim of this study was to identify the TIMP-2 region involved in binding to the previously
identified receptor integrin α3β1, and to determine whether synthetic peptides derived from
this region retained angio-inhibitory and tumor suppressor activity. We demonstrated that the
N-terminal domain of TIMP-2 (N-TIMP-2) binds to α3β1 and inhibits vascular endothelial …
