The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor
Tissue inhibitors of metalloproteinases (TIMPs), the endogenous inhibitors of matrix
metalloproteinases, have been shown to possess biological functions that are independent
of their ability to inhibit matrix metalloproteinases. We have previously shown that the C-
terminal domain of TIMP-2 and, in particular, Loop 6 inhibit capillary endothelial cell
proliferation and angiogenesis both in vitro and in vivo. To elucidate the mechanism by
which Loop 6 inhibits angiogenesis, we sought to determine whether its biological effects …
metalloproteinases, have been shown to possess biological functions that are independent
of their ability to inhibit matrix metalloproteinases. We have previously shown that the C-
terminal domain of TIMP-2 and, in particular, Loop 6 inhibit capillary endothelial cell
proliferation and angiogenesis both in vitro and in vivo. To elucidate the mechanism by
which Loop 6 inhibits angiogenesis, we sought to determine whether its biological effects …
