[HTML][HTML] Invariant chain induces B cell maturation by activating a TAFII105-NF-κB-dependent transcription program
D Matza, O Wolstein, R Dikstein, I Shachar - Journal of Biological Chemistry, 2001 - ASBMB
Early stages of B cell development occur in the bone marrow, resulting in formation of
immature B cells. From there these immature cells migrate to the spleen where they
differentiate to mature cells. This final maturation step is crucial for the B cells to become
responsive to antigens and to participate in the immune response. Recently, invariant chain
(Ii), a major histocompatibility complex class II chaperone, as well as the transcription factors
c-Rel and p65/RelA, were found to play a role in the final antigen-independent differentiation …
immature B cells. From there these immature cells migrate to the spleen where they
differentiate to mature cells. This final maturation step is crucial for the B cells to become
responsive to antigens and to participate in the immune response. Recently, invariant chain
(Ii), a major histocompatibility complex class II chaperone, as well as the transcription factors
c-Rel and p65/RelA, were found to play a role in the final antigen-independent differentiation …