Role of IL-5 in the innate immune system and disease control
K Takatsu, B Moon, A Itakura, Y Tsukamoto… - International Congress …, 2005 - Elsevier
Mature B cells expressing surface IgM as B cell receptor (BCR) consist of two B-cell
subpopulations, B-1 and B-2 cells that regulate innate and acquired immunity, respectively.
B-1 cells become natural Ig-producing plasma cells in response to natural ligands or self-
antigens. Mature B-2 cells proliferate and differentiate into Ig-producing plasma cells under
the influence of T helper (Th) cells. Antigen stimulation of B-2 cells induces class switch
recombination (CSR) from IgM to other isotypes that is regulated by cytokines and activation …
subpopulations, B-1 and B-2 cells that regulate innate and acquired immunity, respectively.
B-1 cells become natural Ig-producing plasma cells in response to natural ligands or self-
antigens. Mature B-2 cells proliferate and differentiate into Ig-producing plasma cells under
the influence of T helper (Th) cells. Antigen stimulation of B-2 cells induces class switch
recombination (CSR) from IgM to other isotypes that is regulated by cytokines and activation …