[HTML][HTML] Loss of cyclin-dependent kinase 2 in the pancreas links primary β-cell dysfunction to progressive depletion of β-cell mass and diabetes
SY Kim, JH Lee, MJ Merrins, O Gavrilova… - Journal of Biological …, 2017 - ASBMB
The failure of pancreatic islet β-cells is a major contributor to the etiology of type 2 diabetes.
β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this
failure, although it is unclear whether they are molecularly linked. Here, we show that the
cell cycle regulator, cyclin-dependent kinase 2 (CDK2), couples primary β-cell dysfunction to
the progressive deterioration of β-cell mass in diabetes. Mice with pancreas-specific deletion
of Cdk2 are glucose-intolerant, primarily due to defects in glucose-stimulated insulin …
β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this
failure, although it is unclear whether they are molecularly linked. Here, we show that the
cell cycle regulator, cyclin-dependent kinase 2 (CDK2), couples primary β-cell dysfunction to
the progressive deterioration of β-cell mass in diabetes. Mice with pancreas-specific deletion
of Cdk2 are glucose-intolerant, primarily due to defects in glucose-stimulated insulin …