Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes
A Noske, LA Henricksen, B LaFleur… - … and molecular pathology, 2015 - Elsevier
Background CCNE1 is frequently amplified in high grade serous ovarian cancer and may
serve as a target for ovarian cancer treatment. URI is closely related to CCNE1 at the 19q12
amplicon and may also contribute to the oncogenic effect. Our objective was to investigate
the relevance of CCNE1 and URI gene amplification and protein expression in different
histological subtypes of epithelial ovarian cancer (EOC). Methods A novel dual-color 19q12
in situ hybridization (ISH), covering CCNE1 and URI, and chromosome 19 as a surrogate …
serve as a target for ovarian cancer treatment. URI is closely related to CCNE1 at the 19q12
amplicon and may also contribute to the oncogenic effect. Our objective was to investigate
the relevance of CCNE1 and URI gene amplification and protein expression in different
histological subtypes of epithelial ovarian cancer (EOC). Methods A novel dual-color 19q12
in situ hybridization (ISH), covering CCNE1 and URI, and chromosome 19 as a surrogate …