Value of PAX 8 immunostaining in tumor diagnosis: a review and update
NG Ordóñez - Advances in anatomic pathology, 2012 - journals.lww.com
PAX 8 is a transcription factor involved in the regulation of organogenesis of the thyroid
gland, kidney, and Müllerian system. Recent studies have shown that, among tumors, PAX 8
is commonly expressed in epithelial tumors of the thyroid and parathyroid glands, kidney,
thymus, and female genital tract. Although PAX 8 expression has also been reported in
certain neuroendocrine tumors, including well-differentiated pancreatic neuroendocrine
tumors, and duodenal and rectal carcinoids, as well as in B-cell lymphomas, it has recently …
gland, kidney, and Müllerian system. Recent studies have shown that, among tumors, PAX 8
is commonly expressed in epithelial tumors of the thyroid and parathyroid glands, kidney,
thymus, and female genital tract. Although PAX 8 expression has also been reported in
certain neuroendocrine tumors, including well-differentiated pancreatic neuroendocrine
tumors, and duodenal and rectal carcinoids, as well as in B-cell lymphomas, it has recently …