Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implications
JW Carlson, EA Jarboe, D Kindelberger… - International journal …, 2010 - journals.lww.com
Serous tubal intraepithelial carcinoma (STIC) is detected in between 5% and 7% of women
undergoing risk-reduction salpingooophorectomy for mutations in the BRCA1 or 2 genes
(BRCA+), and seems to play a role in the pathogenesis of many ovarian and “primary
peritoneal” serous carcinomas. The recognition of STIC is germane to the management of
BRCA+ women; however, the diagnostic reproducibility of STIC is unknown. Twenty-one
cases were selected and classified as STIC or benign, using both hematoxylin and eosin …
undergoing risk-reduction salpingooophorectomy for mutations in the BRCA1 or 2 genes
(BRCA+), and seems to play a role in the pathogenesis of many ovarian and “primary
peritoneal” serous carcinomas. The recognition of STIC is germane to the management of
BRCA+ women; however, the diagnostic reproducibility of STIC is unknown. Twenty-one
cases were selected and classified as STIC or benign, using both hematoxylin and eosin …