Central nervous system circuits that control body temperature

CJ Madden, SF Morrison - Neuroscience letters, 2019 - Elsevier
Neuroscience letters, 2019Elsevier
Maintenance of mammalian core body temperature within a narrow range is a fundamental
homeostatic process to optimize cellular and tissue function, and to improve survival in
adverse thermal environments. Body temperature is maintained during a broad range of
environmental and physiological challenges by central nervous system circuits that process
thermal afferent inputs from the skin and the body core to control the activity of
thermoeffectors. These include thermoregulatory behaviors, cutaneous vasomotion …
Abstract
Maintenance of mammalian core body temperature within a narrow range is a fundamental homeostatic process to optimize cellular and tissue function, and to improve survival in adverse thermal environments. Body temperature is maintained during a broad range of environmental and physiological challenges by central nervous system circuits that process thermal afferent inputs from the skin and the body core to control the activity of thermoeffectors. These include thermoregulatory behaviors, cutaneous vasomotion (vasoconstriction and, in humans, active vasodilation), thermogenesis (shivering and brown adipose tissue), evaporative heat loss (salivary spreading in rodents, and human sweating). This review provides an overview of the central nervous system circuits for thermoregulatory reflex regulation of thermoeffectors.
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