Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells
DC Rockey, L Fouassier, JJ Chung, A Carayon… - Hepatology, 1998 - journals.lww.com
Endothelin (ET) peptides have been implicated in the pathogenesis of several biological
processes within the liver. ET levels are elevated in the circulation of patients with cirrhosis,
and recent data suggest that ET may be overproduced in the liver itself in this condition. The
aims of the current study were to elucidate the cellular source and expression of endothelin-
1 (ET-1) in normal and injured liver, and to investigate its biological effects on stellate cells,
the primary target of ETs in the liver. In normal hepatic cells, preproET-1 messenger RNA …
processes within the liver. ET levels are elevated in the circulation of patients with cirrhosis,
and recent data suggest that ET may be overproduced in the liver itself in this condition. The
aims of the current study were to elucidate the cellular source and expression of endothelin-
1 (ET-1) in normal and injured liver, and to investigate its biological effects on stellate cells,
the primary target of ETs in the liver. In normal hepatic cells, preproET-1 messenger RNA …