[HTML][HTML] Synergistic induction of endothelin-1 by tumor necrosis factor α and interferon γ is due to enhanced NF-κB binding and histone acetylation at specific κB sites
SJ Wort, M Ito, PC Chou, SK Mc Master… - Journal of Biological …, 2009 - ASBMB
Endothelin-1 (ET-1) is a potent vasoconstrictor and co-mitogen for vascular smooth muscle
and is implicated in pulmonary vascular remodeling and the development of pulmonary
arterial hypertension. Vascular smooth muscle is an important source of ET-1. Here we
demonstrate synergistic induction of preproET-1 message RNA and release of mature
peptide by a combination of tumor necrosis factor α (TNFα) and interferon γ (IFNγ) in primary
human pulmonary artery smooth muscle cells. This induction was prevented by pretreatment …
and is implicated in pulmonary vascular remodeling and the development of pulmonary
arterial hypertension. Vascular smooth muscle is an important source of ET-1. Here we
demonstrate synergistic induction of preproET-1 message RNA and release of mature
peptide by a combination of tumor necrosis factor α (TNFα) and interferon γ (IFNγ) in primary
human pulmonary artery smooth muscle cells. This induction was prevented by pretreatment …