[HTML][HTML] Risk of venous thromboembolism in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis
B Boonpheng, P Ungprasert - Sarcoidosis, Vasculitis, and Diffuse …, 2018 - ncbi.nlm.nih.gov
Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018•ncbi.nlm.nih.gov
Background: Recent studies have suggested that patients with idiopathic pulmonary fibrosis
(IPF) may have a higher risk of venous thromboembolism (VTE) compared to general
population even though the results were inconsistent. Objective: To investigate the risk of
VTE among patients with IPF. Methods: Comprehensive literature review using MEDLINE
and EMBASE database were performed to identify studies that compared the risk of VTE
among patients with IPF to general population. Effect estimates from each study were …
(IPF) may have a higher risk of venous thromboembolism (VTE) compared to general
population even though the results were inconsistent. Objective: To investigate the risk of
VTE among patients with IPF. Methods: Comprehensive literature review using MEDLINE
and EMBASE database were performed to identify studies that compared the risk of VTE
among patients with IPF to general population. Effect estimates from each study were …
Background
Recent studies have suggested that patients with idiopathic pulmonary fibrosis (IPF) may have a higher risk of venous thromboembolism (VTE) compared to general population even though the results were inconsistent. Objective
To investigate the risk of VTE among patients with IPF. Methods
Comprehensive literature review using MEDLINE and EMBASE database were performed to identify studies that compared the risk of VTE among patients with IPF to general population. Effect estimates from each study were combined together using random effect model, generic inverse variance method of DerSimonian and Laird. Results
Out of 510 retrieved articles, 5 studies met the inclusion criteria and were included in the meta-analysis. A significant risk of VTE in patients with IPF was observed with the pooled risk ratio of 2.11 (95% confidence interval, 1.28-3.48). The heterogeneity was moderate with I 2 of 64%. Conclusion
An approximately 2-fold increased risk of VTE among patients with IPF was observed in this meta-analysis.(Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 109-114)ncbi.nlm.nih.gov