Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
M Boerma, Q Fu, J Wang, DS Loose… - Blood coagulation & …, 2008 - journals.lww.com
Inhibitors of Rho kinase (ROCK) are a relatively new class of drugs with potential benefits in
oncology, neurology, and fibrotic and cardiovascular diseases. ROCK inhibitors modulate
many cellular functions, some of which are similar to the pleiotropic effects of statins,
suggesting additive or synergistic properties. Studies to date have used compounds that
inhibit both isoforms of ROCK, ROCK1 and ROCK2. This study was designed to compare
gene expression profiles of atorvastatin with the newly developed ROCK2 inhibitor SLx …
oncology, neurology, and fibrotic and cardiovascular diseases. ROCK inhibitors modulate
many cellular functions, some of which are similar to the pleiotropic effects of statins,
suggesting additive or synergistic properties. Studies to date have used compounds that
inhibit both isoforms of ROCK, ROCK1 and ROCK2. This study was designed to compare
gene expression profiles of atorvastatin with the newly developed ROCK2 inhibitor SLx …