Glucocorticoids regulate many crucial biologic functions through their cytoplasmic/nuclear
glucocorticoid receptors (GR). Excess, deficiency, or alteration in tissue sensitivity to
glucocorticoids has been associated with major causes of human morbidity and mortality.
Brx, a cytoplasmic Rho family guanine nucleotide exchange factor, binds to and influences
the activity of several nuclear hormone receptors. We examined the functional and
molecular interactions between GR and Brx. The glucocorticoid sensitivity of lymphocytes …