The Rho family of GTP binding proteins, also commonly referred to as the Rho GTPases, are
master regulators of the platelet cytoskeleton and platelet function. These low‐molecular‐
weight or 'small'GTPases act as signaling switches in the spatial and temporal transduction,
and amplification of signals from platelet cell surface receptors to the intracellular signaling
pathways that drive platelet function. The Rho GTPase family members RhoA, Cdc42 and
Rac1 have emerged as key regulators in the dynamics of the actin cytoskeleton in platelets …