[HTML][HTML] Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium
JA Gullicksrud, A Sateriale, JB Engiles, AR Gibson… - Mucosal …, 2022 - Elsevier
The intestinal parasite, Cryptosporidium, is a major contributor to global child mortality and
causes opportunistic infection in immune deficient individuals. Innate resistance to
Cryptosporidium, which specifically invades enterocytes, is dependent on the production of
IFN-γ, yet whether enterocytes contribute to parasite control is poorly understood. In this
study, utilizing a mouse-adapted strain of C. parvum, we show that epithelial-derived IL-18
synergized with IL-12 to stimulate innate lymphoid cell (ILC) production of IFN-γ required for …
causes opportunistic infection in immune deficient individuals. Innate resistance to
Cryptosporidium, which specifically invades enterocytes, is dependent on the production of
IFN-γ, yet whether enterocytes contribute to parasite control is poorly understood. In this
study, utilizing a mouse-adapted strain of C. parvum, we show that epithelial-derived IL-18
synergized with IL-12 to stimulate innate lymphoid cell (ILC) production of IFN-γ required for …