[HTML][HTML] Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection
P Treerat, O Prince, A Cruz-Lagunas… - Mucosal …, 2017 - Elsevier
Approximately 2 billion people are infected with Mycobacterium tuberculosis (Mtb), resulting
in 1.4 million deaths every year. Among Mtb-infected individuals, clinical isolates belonging
to the W-Beijing lineage are increasingly prevalent, associated with drug resistance, and
cause severe disease immunopathology in animal models. Therefore, it is exceedingly
important to identify the immune mechanisms that mediate protection against rapidly
emerging Mtb strains, such as W-Beijing lineage. IL-22 is a member of the IL-10 family of …
in 1.4 million deaths every year. Among Mtb-infected individuals, clinical isolates belonging
to the W-Beijing lineage are increasingly prevalent, associated with drug resistance, and
cause severe disease immunopathology in animal models. Therefore, it is exceedingly
important to identify the immune mechanisms that mediate protection against rapidly
emerging Mtb strains, such as W-Beijing lineage. IL-22 is a member of the IL-10 family of …