[HTML][HTML] Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins*♦
Mammalian sirtuins (SIRT1 through SIRT7) are members of a highly conserved family of
NAD+-dependent protein deacetylases that function in metabolism, genome maintenance,
and stress responses. Emerging evidence suggests that some sirtuins display substrate
specificity toward other acyl groups attached to the lysine ϵ-amine. SIRT6 was recently
reported to preferentially hydrolyze long-chain fatty acyl groups over acetyl groups. Here we
investigated the catalytic ability of all sirtuins to hydrolyze 13 different acyl groups from …
NAD+-dependent protein deacetylases that function in metabolism, genome maintenance,
and stress responses. Emerging evidence suggests that some sirtuins display substrate
specificity toward other acyl groups attached to the lysine ϵ-amine. SIRT6 was recently
reported to preferentially hydrolyze long-chain fatty acyl groups over acetyl groups. Here we
investigated the catalytic ability of all sirtuins to hydrolyze 13 different acyl groups from …