CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis
JE Turner, HJ Paust, OM Steinmetz… - Journal of the …, 2010 - journals.lww.com
T cells recruited to the kidney contribute to tissue damage in crescentic and proliferative
glomerulonephritides. Chemokines and their receptors regulate T cell trafficking, but the
expression profile and functional importance of chemokine receptors for renal CD4+ T cell
subsets are incompletely understood. In this study, we observed that renal FoxP3+ CD4+
regulatory T cells (Tregs) and IL-17–producing CD4+ T (Th17) cells express the chemokine
receptor CCR6, whereas IFNγ-producing Th1 cells are CCR6−. Induction of experimental …
glomerulonephritides. Chemokines and their receptors regulate T cell trafficking, but the
expression profile and functional importance of chemokine receptors for renal CD4+ T cell
subsets are incompletely understood. In this study, we observed that renal FoxP3+ CD4+
regulatory T cells (Tregs) and IL-17–producing CD4+ T (Th17) cells express the chemokine
receptor CCR6, whereas IFNγ-producing Th1 cells are CCR6−. Induction of experimental …