[HTML][HTML] Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes
S Oka, T Hirata, W Suzuki, D Naito, Y Chen… - Journal of Biological …, 2017 - ASBMB
Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange
reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart
against stresses, such as ischemia and pressure overload. Mechanistic target of rapamycin
(mTOR) is a serine/threonine kinase that regulates cell growth, metabolism, and survival. We
have shown previously that mTOR activity is increased in response to myocardial ischemia–
reperfusion injury. However, whether Trx1 interacts with mTOR to preserve heart function …
reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart
against stresses, such as ischemia and pressure overload. Mechanistic target of rapamycin
(mTOR) is a serine/threonine kinase that regulates cell growth, metabolism, and survival. We
have shown previously that mTOR activity is increased in response to myocardial ischemia–
reperfusion injury. However, whether Trx1 interacts with mTOR to preserve heart function …