Trimetazidine alone or in combination with gemcitabine and/or abraxane decreased cell viability, migration and ATP levels and induced apoptosis of human …
ZA Şekeroğlu, V Şekeroğlu, S Işık, B Aydın - Clinics and Research in …, 2021 - Elsevier
Background Trimetazidine (TMZ) is an anti-ischemic agent that can inhibit the fatty acid
oxidation. It has been stated that inhibition of fatty acid oxidation may be an acceptable
approach to cancer treatment. Methods We examined the effects of TMZ alone or together
with abraxane (ABX) and/or gemcitabine (GEM) on cell viability, apoptosis, adhesion,
migration and ATP levels of human pancreatic cancer cell line PANC-1. Results TMZ
significantly reduced the cell viability at higher concentrations. Lower cell viability values …
oxidation. It has been stated that inhibition of fatty acid oxidation may be an acceptable
approach to cancer treatment. Methods We examined the effects of TMZ alone or together
with abraxane (ABX) and/or gemcitabine (GEM) on cell viability, apoptosis, adhesion,
migration and ATP levels of human pancreatic cancer cell line PANC-1. Results TMZ
significantly reduced the cell viability at higher concentrations. Lower cell viability values …
