[HTML][HTML] Amino acids regulate mTORC1 by an obligate two-step mechanism
J Dyachok, S Earnest, EN Iturraran, MH Cobb… - Journal of Biological …, 2016 - ASBMB
The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with its
nutritional, hormonal, energy, and stress status. Amino acids are critical regulators of
mTORC1 that permit other inputs to mTORC1 activity. However, the roles of individual amino
acids and their interactions in mTORC1 activation are not well understood. Here we
demonstrate that activation of mTORC1 by amino acids includes two discrete and separable
steps: priming and activation. Sensitizing mTORC1 activation by priming amino acids is a …
nutritional, hormonal, energy, and stress status. Amino acids are critical regulators of
mTORC1 that permit other inputs to mTORC1 activity. However, the roles of individual amino
acids and their interactions in mTORC1 activation are not well understood. Here we
demonstrate that activation of mTORC1 by amino acids includes two discrete and separable
steps: priming and activation. Sensitizing mTORC1 activation by priming amino acids is a …
