[HTML][HTML] Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
SA Karumanchi, FH Epstein - Kidney international, 2007 - Elsevier
SA Karumanchi, FH Epstein
Kidney international, 2007•ElsevierElevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the
development of the clinical signs and symptoms of preeclampsia. Placental ischemia has
been suggested as one of the etiological factors that mediate increased sFLT-1 production
in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris
et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1
upregulation and the clinical signs and symptoms of preeclampsia.
development of the clinical signs and symptoms of preeclampsia. Placental ischemia has
been suggested as one of the etiological factors that mediate increased sFLT-1 production
in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris
et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1
upregulation and the clinical signs and symptoms of preeclampsia.
Elevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the development of the clinical signs and symptoms of preeclampsia. Placental ischemia has been suggested as one of the etiological factors that mediate increased sFLT-1 production in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1 upregulation and the clinical signs and symptoms of preeclampsia.
Elsevier