Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane
Cytochrome b5 reductase purified from liver plasma membrane reduces coenzyme Q (CoQ)
in reconstituted liposomes in the absence of cytochrome b5. Both CoQ and its reductase are
responsible for the reduction of the ascorbate free radical at the cell surface. Thus, NADH-
CoQ reductase represents a partial reaction of NADH-AFR reductase in the plasma
membrane. Cytochrome b5 reductase maintains CoQ and ascorbate in their reduced state to
support antioxidations. Reduced CoQ prevents lipid peroxidation in liposomes and plasma …
in reconstituted liposomes in the absence of cytochrome b5. Both CoQ and its reductase are
responsible for the reduction of the ascorbate free radical at the cell surface. Thus, NADH-
CoQ reductase represents a partial reaction of NADH-AFR reductase in the plasma
membrane. Cytochrome b5 reductase maintains CoQ and ascorbate in their reduced state to
support antioxidations. Reduced CoQ prevents lipid peroxidation in liposomes and plasma …