The semaphorins and their receptors as modulators of tumor progression

G Neufeld, Y Mumblat, T Smolkin, S Toledano… - Drug Resistance …, 2016 - Elsevier
The semaphorins were initially characterized as repulsive axon guidance factors. However,
they are currently also recognized as important regulators of diverse biological processes
which include regulation of immune responses, angiogenesis, organogenesis, and a variety
of additional physiological and developmental functions. The semaphorin family consists of
more than 20 genes divided into seven subfamilies, all of which contain the sema domain
signature. They usually transduce signals by activation of receptors belonging to the plexin …