TGF-β regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4
CE Winbanks, B Wang, C Beyer, P Koh, L White… - Journal of Biological …, 2011 - ASBMB
MicroRNAs (miRs) are emerging as prominent players in the regulation of many biological
processes, including myogenic commitment and skeletal muscle formation. Members of the
TGF-β family can influence the proliferation and myogenic differentiation of cells, although it
is presently not clear what role miRNAs play in the TGF-β-mediated control of myogenic
differentiation. Here, we demonstrate in the myogenic C2C12 cell line, and in primary
muscle cells, that miR-206 and miR-29-two miRs that act on transcriptional events …
processes, including myogenic commitment and skeletal muscle formation. Members of the
TGF-β family can influence the proliferation and myogenic differentiation of cells, although it
is presently not clear what role miRNAs play in the TGF-β-mediated control of myogenic
differentiation. Here, we demonstrate in the myogenic C2C12 cell line, and in primary
muscle cells, that miR-206 and miR-29-two miRs that act on transcriptional events …
