Steroids completely reverse albuterol-induced β2-adrenergic receptor tolerance in human small airways
PR Cooper, RA Panettieri Jr - Journal of Allergy and Clinical Immunology, 2008 - Elsevier
BACKGROUND: Evidence suggests that chronic stimulation of β2-adrenergic receptors (β2-
ARs) induces receptor tolerance that limits the efficacy of β-agonists in the treatment of
asthma. The precise mechanisms that induce β2-AR tolerance remain unclear. OBJECTIVE:
We sought to determine whether steroids modulate albuterol-induced β2-AR tolerance in
human small airways. METHODS: β2-AR responsiveness to isoproterenol was
characterized in human precision-cut lung slices (PCLSs) precontracted to carbachol after …
ARs) induces receptor tolerance that limits the efficacy of β-agonists in the treatment of
asthma. The precise mechanisms that induce β2-AR tolerance remain unclear. OBJECTIVE:
We sought to determine whether steroids modulate albuterol-induced β2-AR tolerance in
human small airways. METHODS: β2-AR responsiveness to isoproterenol was
characterized in human precision-cut lung slices (PCLSs) precontracted to carbachol after …