Actin dynamics in pancreatic β-cells is involved in insulin secretion. However, the molecular
mechanisms of the regulation of actin dynamics by intracellular signals in pancreatic β-cells
and its role in phasic insulin secretion are largely unknown. In this study, we elucidate the
regulation of actin dynamics by neuronal Wiskott-Aldrich syndrome protein (N-WASP) and
cofilin in pancreatic β-cells and demonstrate its role in glucose-induced insulin secretion
(GIIS). N-WASP, which promotes actin polymerization through activation of the actin …