High risk of benzo [α] pyrene-induced lung cancer in E160D FEN1 mutant mice
Z Wu, Y Lin, H Xu, H Dai, M Zhou, S Tsao… - Mutation Research …, 2012 - Elsevier
Flap endonuclease 1 (FEN1), a member of the Rad2 nuclease family, possesses 5′ flap
endonuclease (FEN), 5′ exonuclease (EXO), and gap-endonuclease (GEN) activities. The
multiple, structure-specific nuclease activities of FEN1 allow it to process different
intermediate DNA structures during DNA replication and repair. We previously identified a
group of FEN1 mutations and single nucleotide polymorphisms that impair FEN1's EXO and
GEN activities in human cancer patients. We also established a mouse model carrying the …
endonuclease (FEN), 5′ exonuclease (EXO), and gap-endonuclease (GEN) activities. The
multiple, structure-specific nuclease activities of FEN1 allow it to process different
intermediate DNA structures during DNA replication and repair. We previously identified a
group of FEN1 mutations and single nucleotide polymorphisms that impair FEN1's EXO and
GEN activities in human cancer patients. We also established a mouse model carrying the …