[HTML][HTML] The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN …
R Gary, DL Ludwig, HL Cornelius, MA MacInnes… - Journal of Biological …, 1997 - ASBMB
Proliferating cell nuclear antigen (PCNA) is a DNA polymerase accessory factor that is
required for DNA replication during S phase of the cell cycle and for resynthesis during
nucleotide excision repair of damaged DNA. PCNA binds to flap endonuclease 1 (FEN-1), a
structure-specific endonuclease involved in DNA replication. Here we report the direct
physical interaction of PCNA with xeroderma pigmentosum (XP) G, a structure-specific
repair endonuclease that is homologous to FEN-1. We have identified a 28-amino acid …
required for DNA replication during S phase of the cell cycle and for resynthesis during
nucleotide excision repair of damaged DNA. PCNA binds to flap endonuclease 1 (FEN-1), a
structure-specific endonuclease involved in DNA replication. Here we report the direct
physical interaction of PCNA with xeroderma pigmentosum (XP) G, a structure-specific
repair endonuclease that is homologous to FEN-1. We have identified a 28-amino acid …