[HTML][HTML] Amphetamine-induced dopamine efflux: a voltage-sensitive and intracellular Na+-dependent mechanism
H Khoshbouei, H Wang, JD Lechleiter… - Journal of Biological …, 2003 - ASBMB
Amphetamine (AMPH) elicits its behavioral effects by acting on the dopamine (DA)
transporter (DAT) to induce DA overflow into the synaptic cleft. Facilitated exchange diffusion
is the classical model used to describe AMPH-induced DA efflux. This model hypothesizes
that AMPH-induced DA efflux is mediated by DAT and results from the transport of AMPH
into the cell followed by a counter movement of DA out to the extracellular compartment. To
further characterize the action of AMPH, we used the patch clamp technique in the whole …
transporter (DAT) to induce DA overflow into the synaptic cleft. Facilitated exchange diffusion
is the classical model used to describe AMPH-induced DA efflux. This model hypothesizes
that AMPH-induced DA efflux is mediated by DAT and results from the transport of AMPH
into the cell followed by a counter movement of DA out to the extracellular compartment. To
further characterize the action of AMPH, we used the patch clamp technique in the whole …