[HTML][HTML] De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer
M Takeda, I Okamoto, Y Fujita, T Arao, H Ito… - Journal of Thoracic …, 2010 - Elsevier
M Takeda, I Okamoto, Y Fujita, T Arao, H Ito, M Fukuoka, K Nishio, K Nakagawa
Journal of Thoracic Oncology, 2010•ElsevierBackground Somatic mutations in the epidermal growth factor receptor (EGFR) gene are a
predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with
non-small cell lung cancer (NSCLC). However, mechanisms of de novo resistance to these
drugs in patients harboring EGFR mutations have remained unclear. We examined whether
the mutational status of KRAS might be associated with primary resistance to EGFR-TKIs in
EGFR mutation-positive patients with NSCLC. Methods Forty patients with NSCLC with …
predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with
non-small cell lung cancer (NSCLC). However, mechanisms of de novo resistance to these
drugs in patients harboring EGFR mutations have remained unclear. We examined whether
the mutational status of KRAS might be associated with primary resistance to EGFR-TKIs in
EGFR mutation-positive patients with NSCLC. Methods Forty patients with NSCLC with …
Background
Somatic mutations in the epidermal growth factor receptor (EGFR) gene are a predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, mechanisms of de novo resistance to these drugs in patients harboring EGFR mutations have remained unclear. We examined whether the mutational status of KRAS might be associated with primary resistance to EGFR-TKIs in EGFR mutation-positive patients with NSCLC.
Methods
Forty patients with NSCLC with EGFR mutations who were treated with gefitinib or erlotinib and had archival tissue specimens available were enrolled in the study. KRAS mutations were analyzed by direct sequencing.
Results
Three (7.5%) of the 40 patients had progressive disease, and two (67%) of these three individuals had both KRAS and EGFR mutations.
Conclusions
Our results suggest that KRAS mutation is a negative predictor of response to EGFR-TKIs in EGFR mutation-positive patients with NSCLC.
Elsevier