Advances in Ewing's sarcoma research: where are we now and what lies ahead?
JL Ordóñez, D Osuna, D Herrero, E de Alava… - Cancer research, 2009 - AACR
JL Ordóñez, D Osuna, D Herrero, E de Alava, J Madoz-Gúrpide
Cancer research, 2009•AACREwing's sarcoma family tumors (EFT) are characterized by specific chromosomal
translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target
gene networks within the context of other signaling pathways, together with the identification
of the initiating cell, and the development of genetically engineered mice will hopefully lead
to biology-based therapeutic strategies for these tumors.[Cancer Res 2009; 69 (18): 7140–
50]
translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target
gene networks within the context of other signaling pathways, together with the identification
of the initiating cell, and the development of genetically engineered mice will hopefully lead
to biology-based therapeutic strategies for these tumors.[Cancer Res 2009; 69 (18): 7140–
50]
Abstract
Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors. [Cancer Res 2009;69(18):7140–50]
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