Recombinant gene expression in vivo within endothelial cells of the arterial wall
EG Nabel, G Plautz, FM Boyce, JC Stanley, GJ Nabel - Science, 1989 - science.org
EG Nabel, G Plautz, FM Boyce, JC Stanley, GJ Nabel
Science, 1989•science.orgA technique for the transfer of endothelial cells and expression of recombinant genes in vivo
could allow the introduction of proteins of therapeutic value in the management of
cardiovascular diseases. Porcine endothelial cells expressing recombinant β-galactosidase
from a murine amphotropic retroviral vector were introduced with a catheter into denuded
iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later
contained endothelial cells expressing β-galactosidase, an indication that they were …
could allow the introduction of proteins of therapeutic value in the management of
cardiovascular diseases. Porcine endothelial cells expressing recombinant β-galactosidase
from a murine amphotropic retroviral vector were introduced with a catheter into denuded
iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later
contained endothelial cells expressing β-galactosidase, an indication that they were …
A technique for the transfer of endothelial cells and expression of recombinant genes in vivo could allow the introduction of proteins of therapeutic value in the management of cardiovascular diseases. Porcine endothelial cells expressing recombinant β-galactosidase from a murine amphotropic retroviral vector were introduced with a catheter into denuded iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later contained endothelial cells expressing β-galactosidase, an indication that they were successfully implanted on the vessel wall.
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