Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system
D Loffing-Cueni, SY Flores, D Sauter… - Journal of the …, 2006 - journals.lww.com
The activity of the epithelial sodium (Na+) channel (ENaC) in the aldosterone-sensitive distal
nephron (ASDN) needs to be tightly regulated to match urinary Na+ excretion with dietary
Na+ intake. The ubiquitin-protein ligase Nedd4-2, which in vitro interacts with ENaC
subunits and reduces ENaC cell surface abundance and activity by ubiquitylation of the
channel, may participate in the control of ENaC. This study confirms in vivo by reverse–
transcriptase–PCR that Nedd4-2 is expressed throughout the nephron and is detectable by …
nephron (ASDN) needs to be tightly regulated to match urinary Na+ excretion with dietary
Na+ intake. The ubiquitin-protein ligase Nedd4-2, which in vitro interacts with ENaC
subunits and reduces ENaC cell surface abundance and activity by ubiquitylation of the
channel, may participate in the control of ENaC. This study confirms in vivo by reverse–
transcriptase–PCR that Nedd4-2 is expressed throughout the nephron and is detectable by …
