Septic arthritis and sepsis are common and feared complications of staphylococcal
infections, and the increasing antibiotic resistance among staphylococci urge the extended
research for virulence factors involved in these diseases. Staphylcoccus aureus produces a
number of virulence factors controlled by several global regulatory genes including agr and
sarA. MgrA is a recently identified global regulator, belonging to the SarA subfamily, which
upregulates expression of several virulence factors including capsule and sortase. In …