[HTML][HTML] Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase
T Tanaka, D Nishimura, RC Wu, M Amano, T Iso… - Journal of Biological …, 2006 - ASBMB
Rho-associated coiled-coil protein kinase (ROCK) is an effector for the small GTPase Rho
and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and
gene expression, primarily through an alteration of actin cytoskeleton dynamics. Here, we
show that ROCK2 is localized in the nucleus and associates with p300 acetyltransferase
both in vitro and in cells. Nuclear ROCK2 is present in a large protein complex and partially
cofractionates with p300 by gel filtration analysis. By immunofluorescence, ROCK2 partially …
and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and
gene expression, primarily through an alteration of actin cytoskeleton dynamics. Here, we
show that ROCK2 is localized in the nucleus and associates with p300 acetyltransferase
both in vitro and in cells. Nuclear ROCK2 is present in a large protein complex and partially
cofractionates with p300 by gel filtration analysis. By immunofluorescence, ROCK2 partially …