Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy) propane phosphonic acid] and AEBSF [4-(2-aminoethyl) …
R Buitrago-Rey, J Olarte… - Journal of Antimicrobial …, 2002 - academic.oup.com
R Buitrago-Rey, J Olarte, JE Gomez-Marin
Journal of Antimicrobial Chemotherapy, 2002•academic.oup.comWe examined the effect of an inhibitor of secretory phospholipase A2 type II (LY311727) and
of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis.
LY311727 did not afford any significant protection and produced earlier mortality compared
with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant
increase in length of survival, and this effect was enhanced when AEBSF was administered
with non-protective doses of pyrimethamine.
of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis.
LY311727 did not afford any significant protection and produced earlier mortality compared
with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant
increase in length of survival, and this effect was enhanced when AEBSF was administered
with non-protective doses of pyrimethamine.
Abstract
We examined the effect of an inhibitor of secretory phospholipase A2 type II (LY311727) and of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis. LY311727 did not afford any significant protection and produced earlier mortality compared with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant increase in length of survival, and this effect was enhanced when AEBSF was administered with non-protective doses of pyrimethamine.
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